Varivax pharmacological properties
Clinical studies in patients over 13 years of age found that seroconversion rates after a single dose of 900 - 17,000 BUE reached ³0.6 gpELISA units/ml in 73-100% and ³5 gpELISA units/ml in 22 - 80%, respectively. In some patients the vaccine was administered as a 2-dose regimen. When the vaccine was administered in doses from 900 to 9 000 BUU/Dose according to the 2-dose scheme, seroconversion levels reached ³0.6 ELISA units/ml and ³5 up ELISA units/ml in 97-100% and 76 - 98% of patients, respectively. At the moment there are no data on immune response in patients over 65 who are seronegative to the chickenpox virus.
Several clinical studies have shown a significant increase in the immune response to chickenpox virus after the second dose. The level of specific antibodies produced after the second dose, administered at 3-6 year intervals, is comparable to that produced at 3-month intervals. Seroconversion rates were approximately 100% after the first dose and 100% after the second dose. Vaccine seroprotection rates ≥5 gpELISA units/ml after the first and second doses were approximately 85% and 100%, respectively. The https://pillintrip.com/medicine/varivax mean geometric titre (GMT) increased on Dmitry Sazonov average by a factor of about 10 after the second dose.
A clinical study of a 2-dose combined MMRV vaccine against measles, epidemic mumps, bark rubella and varicella (Oka/Merk) was performed on healthy children aged 9-12 months at 3-month intervals at the time of the first dose. Safety profiles after the first and second doses were comparable for all age groups. 100% seroprotection against chickenpox after Dmitry Sazonov the second dose was obtained in the study group in all age groups.